A common belief is that evolution generally proceeds towards greater complexity at both the organismal and the genomic level, numerous examples of reductive evolution of parasites and symbionts notwithstanding. However, recent evolutionary reconstructions challenge this notion. Two notable examples are the reconstruction of the complex archaeal ancestor and the intron‐rich ancestor of eukaryotes. In both cases, evolution in most of the lineages was apparently dominated by extensive loss of genes and introns, respectively. These and many other cases of reductive evolution (...) are consistent with a general model composed of two distinct evolutionary phases: the short, explosive, innovation phase that leads to an abrupt increase in genome complexity, followed by a much longer reductive phase, which encompasses either a neutral ratchet of genetic material loss or adaptive genome streamlining. Quantitatively, the evolution of genomes appears to be dominated by reduction and simplification, punctuated by episodes of complexification. (shrink)

Scale-free network models describe many natural and social phenomena. In particular, networks of interacting components of a living cell were shown to possess scale-free properties. A recent study(1) compares the system-level properties of metabolic and information networks in 43 archaeal, bacterial and eukaryal species and claims that the scale-free organization of these networks is more conserved during evolution than their content. BioEssays 24:105–109, 2002. Published 2002 Wiley Periodicals, Inc.

Gender, age, and culturally specific beliefs are often considered relevant to observed variation in social interactions. At present, however, the scientific literature is mixed with respect to the significance of these factors in guiding moral judgments. In this study, we explore the role of each of these factors in moral judgment by presenting the results of a web-based study of Eastern (i.e., Russia) and Western (i.e., USA, UK, Canada) subjects, male and female, and young and old. Participants ( n = (...) 659) responded to hypothetical moral scenarios describing situations where sacrificing one life resulted in saving five others. Though men and women from both types of cultures judged (1) harms caused by action as less permissible than harms caused by omission, (2) means-based harms as less permissible than side-effects, and (3) harms caused by contact as less permissible than by non-contact, men in both cultures delivered more utilitarian judgments (save the five, sacrifice one) than women. Moreover, men from Western cultures were more utilitarian than Russian men, with no differences observed for women. In both cultures, older participants delivered less utilitarian judgments than younger participants. These results suggest that certain core principles may mediate moral judgments across different societies, implying some degree of universality, while also allowing a limited range of variation due to sociocultural factors. (shrink)

In recent years, shared decision-making has become entrenched in the medical literature and the law as the ideal method for involving patients in decisions related to their health care. Shared decision-making represents a compromise between the opposed extremes of paternalistic interactions that limit patients’ control of their health care, and “informed choice” interactions that require physicians to provide technical expertise only, leaving patients to make all treatment decisions on their own. An implicit goal of shared decision-making is to improve medical (...) care by promoting joint participation of patients and physicians in clinical consultations. The model of shared decision-making may, however, inadequately address the health care needs of lower literate patients, a significant portion of the general population.As shared decision-making is widely held as a clinical ideal, we highlight the difficulties that physicians might have in implementing shared decision-making with lower literate patients. (shrink)

Color FilmAs if from darkness, from gloom, from nothing —this moment is sewn through us like a thread —from above our shoulders — from primeval night —a shining river. A flying light.Onto the screen, onto a white calm,onto a cloth, onto the ground of spatial fields,it flies through the eyeless dark,it's as voluminous as seed or salt.And in this theater, where light's been banished,where even streetlight fades away completely,other light channels vibrate,and reflections wander through the eye.The curtains open up — (...) the wings of a gate.The screen shifts our eyes and soulsso that we reach new perspectives,blown by the wind into the changingof colors, landscapes, rooms,we touch fire, earth, water.But no! Not those! And not like that!There's a wall here, the screen's always a wall.So, when the shades are opened and it's over,daylight pours through the aisles,we walk as if from underground corridors,we reach for cigarettes in our pockets.We exit like a flood, like a tide,and start talking again.O reality, blinding and sublime!We learn to love. We learn to see.StanzasThose years are slowly fading.Our house was by the railroad stationwhere engines covered in soot hammeredand invisible locomotives roared at night.Pedestrians passed by our porch,their moods dependent on loveand weather, coats and sorrowscarried over their shoulders, invisibleswords drawn but hesitant — as if awaitingtournament trumpets to launch their lives.The acacia (the one that was cut down later)grew according to a centuries-long spanof rain and sun and, like a lively banner,the windows reflected its green flash.And there was lilac, a skinny creature,diminished from the leaves to the roots.But once a year it flushed numb madlyand flourished although it was in pain.(It's worth mentioning the elderberry —dense, aromatic, and luminous,and how, after trembling on the bush,a rainbow surfaced through the drizzle.)Those lands were also full of winter —Christmassy and audacious, like an invasion,and a piercing whirlwind flew inthrough cold doorways and frozen windows.And in the lanterns oranges burned,buckets clanking through the morning,snow trampled after a blizzard,brown brick ovens roaring inside houses...Those years are fading like those legends,but who will weave us sweeter memories?Elegy for the SixtiesSummer, the smell of a soccer ball, elderberry, currant,couples made out in the evening bushes,and when the twilight descended beyond the river,the stony sidewalks smelled of warm rain.The soccer ball flew over antennas and linden trees,its body leather and cosmic.From grape-covered arbors, with pubescent sobs,songs of the prodigy Robertino spread through the world.The night thickened instantly, the ball meltedin the darkness, lamps lit up in the orchards and porches,a mysterious depth opened in a treetop,the shadows on the faded curtains spoke.The ball never came back: disappeared in the distance.Frogs croaked from neglected fountainsin the park where there were dances every night,where a saxophone wheezed, where they carried knives.The ball remained in the air, and the years unfoldedlike sandy seas, like salty deserts,and spooky carousels horrendously circledand creaked for us, as in a dream, until morning.The Museum of AntiquitiesHow the two of us walkthe cramped labyrinths of an old house!...Tapestries and trumpetsglorify an unknown couple,as if seeingour conspiracy:every toucha warm flash.And then again and againwe passin the mirrors.The clock with blazonsindicates, as always, it's two,and sneaking after usmaybe anguish, maybe a fugue...Passing portraitsand palanquinsan echo of footstepswalks with us.We disappeared somewhere for a long time(for two hundred years?For three hundred?).And when it gets dark,from unheated rooms(I seem to have behaved well,I did nothing wrong),into hot neon lightswe return forever.I carry you in my hand,and life is so vast... (shrink)

The success of deep learning in natural language processing raises intriguing questions about the nature of linguistic meaning and ways in which it can be processed by natural and artificial systems. One such question has to do with subword segmentation algorithms widely employed in language modeling, machine translation, and other tasks since 2016. These algorithms often cut words into semantically opaque pieces, such as ‘period’, ‘on’, ‘t’, and ‘ist’ in ‘period|on|t|ist’. The system then represents the resulting segments in a dense (...) vector space, which is expected to model grammatical relations among them. This representation may in turn be used to map ‘period|on|t|ist’ (English) to ‘par|od|ont|iste’ (French). Thus, instead of being modeled at the lexical level, translation is reformulated more generally as the task of learning the best bilingual mapping between the sequences of subword segments of two languages; and sometimes even between pure character sequences: ‘p|e|r|i|o|d|o|n|t|i|s|t’ → ‘p|a|r|o|d|o|n|t|i|s|t|e’. Such subword segmentations and alignments are at work in highly efficient end-to-end machine translation systems, despite their allegedly opaque nature. The computational value of such processes is unquestionable. But do they have any linguistic or philosophical plausibility? I attempt to cast light on this question by reviewing the relevant details of the subword segmentation algorithms and by relating them to important philosophical and linguistic debates, in the spirit of making artificial intelligence more transparent and explainable. (shrink)

I offer an argument in defense of four-dimensionalism, the view that objects are temporally, as well as spatially extended. The argument is of the inference-to-the-best-explanation variety and is based on relativistic considerations. It deals with the situation in which one and the same object has different three-dimensional shapes at the same time and proceeds by asking what sort of thing it must be in order to present itself in such different ways in various “perspectives” (associated with moving reference frames) without (...) being different from itself. I argue that the best answer is that the object must be four-dimensional. It will then have differing 3D shapes in different perspectives because such shapes are intrinsic properties of its 3D parts. (shrink)

In this paper I develop three different arguments against the thesis that knowledge-how is a kind of knowledge-that. Knowledge-that is widely thought to be subject to an anti-luck condition, a justified or warranted belief condition, and a belief condition, respectively. The arguments I give suggest that if either of these standard assumptions is correct then knowledge-how is not a kind of knowledge-that. In closing I identify a possible alternative to the standard Rylean and intellectualist accounts of knowledge-how. This alternative view (...) illustrates that even if the arguments given here succeed it might still be reasonable to hold that knowing how to do something is a matter of standing in an intentional relation to a proposition other than the knowledge-that relation. (shrink)

How should intellectualists respond to apparent Gettier-style counterexamples? Stanley offers an orthodox response which rejects the claim that the subjects in such scenarios possess knowledge-how. I argue that intellectualists should embrace a revisionary response according to which knowledge-how is a distinctively practical species of knowledge-that that is compatible with Gettier-style luck.

It is often said that ‘what it is like’-knowledge cannot be acquired by consulting testimony or reading books [Lewis 1998; Paul 2014; 2015a]. However, people also routinely consult books like What It Is Like to Go to War [Marlantes 2014], and countless ‘what it is like’ articles and youtube videos, in the apparent hope of gaining knowledge about what it is like to have experiences they have not had themselves. This article examines this puzzle and tries to solve it by (...) appealing to recent work on knowing-wh ascriptions. In closing I indicate the wider significance of these ideas by showing how they can help us to evaluate prominent arguments by Paul [2014; 2015a] concerning transformative experiences. (shrink)

Debates about material coincidence tend to start with common-sense intuitions but quickly leave them behind and lead to highly problematic conclusions. Reconciling the latter with common sense is the next stage in the process, which often requires revision of some of the initial beliefs and has been used to adjudicate many rather abstract and technical proposals in the metaphysics of composition and persistence, ranging from natural (constitutionalism) to radical (nihilism). -/- I have no disagreement with this overall strategy: theories do (...) need to turn abstract at some point, move beyond common sense, and eventually force upon us interesting, novel, and often counterintuitive revisions in our overall conceptual scheme. This applies to all theoretical areas, and contemporary metaphysics is no exception. But while the latter is widely regarded as being quite extreme in this respect, I want to argue that, in one sense, it is not extreme enough. I do it by developing a new case of material coincidence that is initially motivated not by common sense but by physical considerations, and is not susceptible to any of the standard solutions. -/- One lesson of science is its ability to expand our imagination beyond the limits of common sense. This may have importance for metaphysics too. (shrink)

I offer a new criticism of the argument from vagueness to four-dimensionalism [Sider 2001. The argument is modelled after an older argument for mereological universalism [Lewis 1986 and may be looked upon as a tightened-up and extended version of the latter. While I agree with other critics [Koslicki 2003; Markosian 2004 that the argument from vagueness fails precisely because of this affinity, my recipe for dealing with it is different. I reject the assumption, shared by Sider with his opponents, that (...) synchronic composition and ‘minimal diachronic fusion’ are sufficiently similar to use considerations inspired by the analysis of the former to bear on the latter. My objection to a crucial premise of the argument from vagueness turns on the relevant aspect of dissimilarity between these two cases. (shrink)

This commentary suggests that the ongoing malaise of biomedical research results from adopting a doctrine that is incompatible with the principles of creative scientific discovery and thus should be treated as a mental rather than somatic disorder. I overview the progression of the malaise, outline the doctrine and the history of its marriage to science, formulate the diagnosis, justify it by reviewing the symptoms of the malaise, and suggest how to begin to cure the disease.

This is the first part of a two part work on the monadic theory of short orders (embedding neither ω 1 nor ω 1 * ). This part provides the technical groundwork for decidability results. Other applications are possible.

I examine the issue of persistence over time in thecontext of the special theory of relativity (SR). Thefour-dimensional ontology of perduring objects isclearly favored by SR. But it is a different questionif and to what extent this ontology is required, andthe rival endurantist ontology ruled out, by thistheory. In addressing this question, I take theessential idea of endurantism, that objects are whollypresent at single moments of time, and argue that itcommits one to unacceptable conclusions regardingcoexistence, in the context of SR. (...) I then propose anddiscuss a plausible account of coexistence forperduring objects, which is free of these defects. This leaves the endurantist room for some maneuvers. I consider them and show that they do not really helpthe endurantist out. She can accommodate the notionof coexistence in the relativistic framework only atthe cost of renouncing central endurantist intuitions. (shrink)

This chapter explores the relationship between knowing-how and skill, as well other success-in-action notions like dispositions and abilities. I offer a new view of knowledge-how which combines elements of both intellectualism and Ryleanism. According to this view, knowing how to perform an action is both a kind of knowing-that (in accord with intellectualism) and a complex multi-track dispositional state (in accord with Ryle’s view of knowing-how). I argue that this new view—what I call practical attitude intellectualism—offers an attractive set of (...) solutions to various puzzles concerning the connections between knowing-how and abilities and skills to perform intentional actions. (shrink)

I focus on two aspects: The complexity of understanding heart rate variability, which is not acknowledged in Porges’s polyvagal theory; and The goals of self-regulation that vary ….

Composition, persistence, vagueness, and more constitute an interconnected network of problems. My criticism of Hud Hudson's provocative claims made in a recent paper (Hudson 2002) was focused almost exclusively on the issue of diachronic composition (Balashov 2003). Hudson's response (2003) has highlighted the dangers of such isolationism. But I want to hold to my strategy to the end. Part of the reason is to evade the appalling responsibility of presenting a full-blown theory of all the above phenomena; I must confess (...) that I do not have such a theory. At the same time, I contend that diachronic composition can be profitably carved out from the medley of the surrounding issues more or less at the joints provided by nature itself. And I do subscribe to some sort of realism about the joints of nature. (shrink)

Although considerations based on contemporary space-time theories, such as special and general relativity, seem highly relevant to the debate about persistence, their significance has not been duly appreciated. My goal in this paper is twofold: (1) to reformulate the rival positions in the debate (i.e., endurantism [three-dimensionalism] and perdurantism [four-dimensionalism, the doctrine of temporal parts]) in the framework of special relativistic space-time; and (2) to argue that, when so reformulated, perdurantism exhibits explanatory advantages over endurantism. The argument builds on the (...) fact that four-dimensional entities extended in space as well as time are relativistically invariant in a way three-dimensional entities are not. (shrink)

The topic of self-interest raises large and intractable philosophical questions–most obviously, the question “In what does self-interest consist?” The concept, as opposed to the content of self-interest, however, seems clear enough. Self-interest is interest in one's own good. To act self-interestedly is to act on the motive of advancing one's own good. Whether what one does actually is in one's self-interest depends on whether it actually does advance, or at least, minimize the decline of, one's own good. Though it may (...) be difficult to tell whether a person is motivated by self-interest in a particular instance, and difficult also to determine whether a given act or decision really is in one's self-interest, the meaning of the claims in question seems unproblematic. My main concern in this essay is to make a point about the content of self-interest. Specifically I shall put forward the view that meaningfulness, in a sense I shall elaborate, is an important element of a good life. It follows, then, that it is part of an enlightened self-interest that one wants to secure meaning in one's life, or, at any rate, to allow and promote meaningful activity within it. Accepting this substantial conception of self-interest, however, carries with it a curious consequence: the concept of self-interest which formerly seemed so clear begins to grow fuzzy. Fortunately, it comes to seem less important as well. In Reasons and Persons, Derek Parfit distinguishes three sorts of theories about self-interest–hedonistic theories, preference theories, and what he calls “objective-list theories." Hedonistic theories hold that one's good is a matter of the felt quality of one's experiences. (shrink)

February 21st will mark the two-hundred-and-fiftieth anniversary of the death of Spinoza, which occurred on February 21st, 1677. The visitor to the Hague may still see, in the Paviljoensgragt, the small two-storied house in the top rooms of which Spinoza spent the last six years of his short life. A tablet placed under the top windows commemorates the fact. It was in these rooms that Spinoza completed his Ethica, which may perhaps be regarded as the greatest masterpiece in the history (...) of Metaphysics. The house is in danger of being pulled down, and the Spinoza Society is endeavouring to secure it as a memorial to Spinoza, and a centre of philosophic studies. It is not so long since the house-breakers I had their way with the home of Erasmus in Rotterdam. It would be sad indeed if the abode of another of the greatest Humanists were to meet with a like fate. It is to be hoped that the revived I interest in Spinoza which we are witnessing now may take the I practical form of saving this precious relic, which may well serve to promote the peace and goodwill among men which Spinoza had so much at heart. (shrink)

Are shapes of objects intrinsic to them? The issue has been intensely debated. Special relativity (SR) adds a new dimension to it by relativizing three-dimensional (3D) shapes not just to times, but to times-in-frames. Arguably, however, such relativized spatial shapes are mere perspectival representations of an invariant, hence intrinsic, four-dimensional (4D) shape of an object in Minkowski spacetime. In a recent note, Matthew Davidson questions the intrinsicality of 4D shapes in SR. I show that his conclusion and the reasoning behind (...) it are in error. (shrink)

Paul (2014, 2015a) argues that one cannot rationally decide whether to have a transformative experience by trying to form judgments, in advance, about (i) what it would feel like to have that experience, and (ii) the subjective value of having such an experience. The problem is if you haven’t had the experience then you cannot know what it is like, and you need to know what it is like to assess its value. However, in earlier work I argued that ‘what (...) it is like’-knowledge comes in degrees, and I briefly suggested that, consequently, some instances of Paul’s argument schema might commit a fallacy of equivocation. The aim of this paper is to further explore and strengthen this objection by, first, offering a new argument—the modelling argument—in support of it, and then by evaluating a range of replies that might be given to this objection on Paul’s behalf. I conclude that each reply either fails or, at best, only partially succeeds in defending some but not all instances of Paul’s argument schema. In closing, I consider how we might revise Paul’s concepts of transformative experiences and choices in response to this conclusion. (shrink)

I had excruciating back pain last night. The next day I went to a spa and the pain disappeared. Psychologically speaking, my pain is gone. Where is it, speaking ontologically? Atheorists have an easy time here (more or less). But B-theorists who think that persons persist by enduring are in trouble. Why am I finding myself at this particular time, with this particular set of experiences, rather than at numerous other times, with different experiences, despite the fact that all times (...) are on the same ontological footing and I am wholly present at all of them? I argue that the Puzzle of the Experience of the Present is a real challenge for B-theorists, and the best way to deal with it is to adopt the stage view of persistence. (shrink)

Hawley introduced the idea of the client's perspective on knowledge, which she used to illuminate knowing-how and cases of epistemic injustice involving knowing-how. In this paper, I explore how Hawley's idea might be used to illuminate not only knowing-how, but other forms of knowledge that, like knowing-how, are often claimed to be distinct from mere knowing-that, focusing on the case studies of moral understanding and ‘what it is like’-knowledge.

This essay defends a reading of Hegel as a metametaphysical antirealist. Metametaphysical antirealism is a denial that metaphysics has as its subject matter answers to theoretical questions about the mind-independent world. Hence, on this view, metaphysical questions are not, in principle, knowledge transcendent. I hold that Hegel presents a version of metametaphysical antirealism in the Science of Logic because he pursues his project by suspending reference to all supposed objects of metaphysical theory as practiced before him. Hegel introduces reference in (...) his theory only by the self-reference of thought to itself in the Doctrine of the Concept. I motivate the relevance of Hegel’s approach to metaphysics by comparing it to Kit Fine’s (2017) concept of “naïve metaphysics.” I argue that Hegel’s theory results from a comprehensively naïve metaphysics. (shrink)

I offer an argument in defense of four-dimensionalism, the view that objects are temporally, as well as spatially extended. The argument is of the inference-to-the-best-explanation variety and is based on relativistic considerations. It deals with the situation in which one and the same object has different three-dimensional shapes at the same time and proceeds by asking what sort of thing it must be in order to present itself in such different ways in various "perspectives" (associated with moving reference frames) without (...) being different from itself. I argue that the best answer is that the object must be four-dimensional. It will then have differing 3D shapes in different perspectives because such shapes are intrinsic properties of its 3D parts. (shrink)

In a recent Inquiry article Louis Pascal argues that the problem of massive starvation in the modern world is the result of a genetically-based human propensity to produce as many offspring as possible, regardless of ecological conditions. In this paper biological and anthropological objections to Pascal's thesis are discussed as well as the conclusions he draws from it. It is suggested that natural selection has produced humans who are flexible in their reproductive behavior in order to cope with rapidly changing (...) environments. The implications of both arguments for the population movement and the attempt to eliminate starvation are discussed. (shrink)

Is there a successful regress argument against intellectualism? In this article I defend the negative answer. I begin by defending Stanley and Williamson's (2001) critique of the contemplation regress against Noë (2005). I then identify a new argument – the employment regress – that is designed to succeed where the contemplation regress fails, and which I take to be the most basic and plausible form of a regress argument against intellectualism. However, I argue that the employment regress still fails. Drawing (...) on the previous discussion, I criticise further regress arguments given by Hetherington (2006) and Noë (2005). (shrink)

What follows for the ability hypothesis reply to the knowledge argument if knowledge-how is just a form of knowledge-that? The obvious answer is that the ability hypothesis is false. For the ability hypothesis says that, when Mary sees red for the first time, Frank Jackson’s super-scientist gains only knowledge-how and not knowledge-that. In this paper I argue that this obvious answer is wrong: a version of the ability hypothesis might be true even if knowledge-how is a form of knowledge-that. To (...) establish this conclusion I utilize Jason Stanley and Timothy Williamson’s well-known account of knowledge-how as “simply a species of propositional knowledge” . I demonstrate that we can restate the core claims of the ability hypothesis – that Mary only gains new knowledge-how and not knowledge-that – within their account of knowledge-how as a species of knowledge-that. I examine the implications of this result for both critics and proponents of the ability hypothesis. (shrink)

This chapter aims to contextualize Confucius' elitism in a contemporaneous sociopolitical and intellectual situation, to distinguish between novel and traditional aspects of his views of the elite's belonging, and to analyze the possible impact of Confucius' ideas on subsequent conceptualizations of social and political hierarchy in late pre‐imperial (i.e., pre‐221 bce) and imperial China. It discusses two central concepts in Confucius' ethical and social thought: that of a “noble man” (junzi), and of a “petty man” (xiaoren). Both are among the (...) key terms in the Analects. By comparing the usages of both terms in the Analects with earlier texts, primarily the Zuo zhuan 左傳 (Zuo Commentary or Zuo Tradition), the chapter demonstrates that Confucius revolutionized the usage of the former term, expanding it to include members of his own shi 士 stratum. (shrink)

To state an important fact about the photon, physicists use such expressions as (1) “the photon has zero (null, vanishing) mass” and (2) “the photon is (a) massless (particle)” interchangeably. Both (1) and (2) express the fact that the photon has no non-zero mass. However, statements (1) and (2) disagree about a further fact: (1) attributes to the photon the property of zero-masshood whereas (2) denies that the photon has any mass at all. But is there really a difference between (...) saying that something has zero mass (charge, spin, etc.) and saying that it has no mass (charge, spin, etc.)? Does the distinction cut any physical or philosophical ice? I argue that the answer to these questions is yes. Put briefly, the claim of this paper is that some zero-value physical quantities are not mere “privations”, “absences” or “holes in being”. They are respectable properties in the same sense in which their non-zero partners are. This, I will show, has implications for the debate between two rival views of the nature of property, dispositionalism and categoricalism. (shrink)

Duhem's and Quine's holistic theses, when properly understood, allow methodologically responsible ways of resolving a conflict between a theoretical system and experience; they only deny the possibility of doing it in an epistemically persuasive way. By developing a "string" model of scientific tests I argue that the pattern of interaction between the elements of a theoretical system arising in response to multiple adverse data can be helpful in locating a "weak spot" in it. Combining this model with anti-holistic arguments of (...) Popper, Greenwood, and Lakatos significantly reinforces their joint power. (shrink)